Topical Ketoconazole Stimulates Hair Growth - Minoxidil & Collagen
Today I found some excellent alopecia / hairloss articles of intrest from Hairlosshelp.com these articles are worth a read.
Topical Ketoconazole stimulates hair growth
Topical application of ketoconazole stimulates hair growth in C3H/HeN mice.Jiang J, Tsuboi R,…
reporter2@hairlosshelp.com (John Ellis)
New method for studying plucked hair follicles
BACKGROUND: There is a need for a technology that can quantitatively assay multiple proteins from a single hair follicle while preserving the morphology of the follicle. For proteomic profiling, the technology should be less labor intensive, with a higher throughput, more quantitative and more reproducible than immunohistochemistry.
OBJECTIVE: To test the ability of a novel method, layered expression scanning of hair (LES-hair) to detect the levels and localization of proteins in plucked hair follicles.
METHODS: LES-hair was used to assay proteins in the plucked hair follicle. Read the rest here ….
How Minoxidil affects collagen
Collagen deposits in fibrotic lesions often display elevated levels of hydroxyallysine (pyridinoline) cross-links. The relation between the occurrence of pyridinoline cross-links and the irreversibility of fibrosis suggests that these cross-links contribute to the aberrant accumulation of collagen. Based on its inhibitory effect on lysyl hydroxylase activity minoxidil has been postulated to possess anti-fibrotic properties by limiting the hydroxylysine supply for hydroxyallysine cross-linking. However, to interfere with hydroxyallysine cross-linking specifically lysyl hydroxylation of the collagen telopeptide should be inhibited, a reaction predominantly catalysed by lysyl hydroxylase (LH) 2b …read the rest here ….
Treatment of female pattern hair loss with oral antiandrogens
University of Melbourne Department of Dermatology, St Vincent’s Hospital, 41 Victoria Parade, Fitzroy 3065, Melbourne, Australia.
BACKGROUND: It has not been conclusively established that female pattern hair loss (FPHL) is either due to androgens or responsive to oral antiandrogen therapy.
OBJECTIVES: To evaluate the efficacy of oral antiandrogen therapy in the management of women with FPHL using standardized photographic techniques (Canfield Scientific), and to identify clinical and histological parameters predictive of clinical response.
METHODS: For this single-centre, before-after, open intervention study, 80 women aged between 12 and 79 years, with FPHL and biopsy-confirmed hair follicle miniaturization [terminal/vellus (T/V) hair ratio < or = 4 : 1] were photographed at baseline and again after receiving a minimum of 12 months of oral antiandrogen therapy. Forty women received spironolactone 200 mg daily and 40 women received cyproterone acetate, either 50 mg daily or 100 mg for 10 days per month if premenopausal. Women using topical minoxidil were excluded. Standardized photographs of the midfrontal and vertex scalp were taken with the head positioned in a stereotactic device. Images were evaluated by a panel of three clinicians experienced in the assessment of FPHL, blinded to patient details and treatment and using a three-point scale…. read the rest here ….
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April 14th, 2006 at 9:00 am
Hello! i had alopecia areata for 2years, i didnt know what to do, i was in the university and it was a nightmare, i lost a lost of hair of my head and i shaved a lot of times, i moved to Illinois and i visited a doctor, he told me “there is not an answer, you have to wait and relax, i dont have nothing to help you” ok, at this point i was confused and tired, then, i got back to Mexico and i got a second opinion about Alopecia Areata, this doctor i visited in Mexico told me “Dont worry, i can give you a cure” and gave me a list to get in the pharmacy, in 3weeks, i was fine, and without alopecia areata, now im fine and i dont worry anymore, i dont remember what is the list he gave me, cuz im living in US again, but i can get the name of the drugs, just i remember Dermatovate and Dilar, i have the name of the doctor and the adress where is his hospital, if u re interesed you can write me, and i ll give you all the details, i have pictures to prove it, and well, i know how the person feel with alopecia areata, so, i wanna help, thanx for reading and write me for more details.